Triclabendazole 250 Mg is a benzimidazole anthelmintic — a medicine that kills parasitic worms. Unlike many other anti-worm drugs, its main target is liver flukes, especially Fasciola hepatica and Fasciola gigantica, parasites that infect the liver and bile ducts of humans and animals.

These infections — known as fascioliasis — can cause abdominal pain, fever, nausea, and liver damage if untreated. The 250 mg tablet strength is common in human and veterinary use, typically based on weight-adjusted dosing.

Standard Dosing and Administration

For humans, the recommended dose is generally 10 mg/kg of body weight. In practical terms, this often means one or two 250 mg tablets taken together (or split over two doses) depending on the person’s body weight and the clinician’s protocol.

WHO and other clinical sources often recommend:

Single 10 mg/kg dose after a meal OR

Two 10 mg/kg doses, 12 hours apart — especially in heavier infestations or repeat treatment.

Taking the medicine with a fatty meal improves absorption and efficacy.

How Effective Is It?

✅ Human Fascioliasis (Liver Fluke Infection)

Clinical trials have shown that triclabendazole is highly effective in humans with fascioliasis:

In one study, cure rates were about 79.4 % with a single 10 mg/kg dose, and 93.9 % when the treatment was given twice on consecutive days. Triclabendazole Buy Online at top pharmacy Medzsupplier.

Other clinical data report cure rates from 70 % up to 100 %, depending on the dose regimen and the population studied.

WHO-linked studies from the 1990s showed cure rates of about 94 % by egg disappearance and about 88 % when also assessing worms in the liver 60 days after treatment.

These figures indicate excellent efficacy compared with most other anthelmintics — especially against both adult and juvenile liver flukes.

Veterinary Context

In livestock (sheep, cattle, goats), triclabendazole is also one of the most effective flukicides:

Studies show very high efficacy — in many cases 95 – 100 % reduction in fluke burden — particularly against both immature and mature flukes.

Efficacy may vary with species and intensity of infection, and resistance issues have been reported in some regions.

Resistance and Treatment Failures

While triclabendazole remains the best available medicine for fascioliasis, there are increasing reports of reduced effectiveness and resistance, especially in veterinary settings where the drug has been used extensively in livestock.

In some livestock studies, liver flukes showed lower responses after repeated use.

Resistance has also been documented in human cases in parts of South America where repeated use was common.

This doesn’t mean the drug doesn’t work — rather it suggests that efficacy may diminish in specific areas or populations, which is why some clinicians may choose repeat dosing or combine treatments.

Mechanism of Action

Triclabendazole works by disrupting the microtubular structures and enzyme systems of liver flukes, impairing their ability to survive and reproduce. It targets both immature and adult stages, which is one reason it’s more effective than many other anthelmintics that only act on adult worms.

Safety and Side Effects

Overall, triclabendazole is well tolerated when used at recommended doses:

Most side effects are mild — abdominal pain, nausea, headache.

Transient increases in liver enzymes have been recorded but typically return to normal.

Some side effects may relate to dead or dying parasites causing temporary biliary discomfort.

Major adverse reactions are uncommon, and the drug is considered safe in many clinical settings under medical supervision.

Conclusion

Triclabendazole 250 mg is one of the most effective drugs for treating liver fluke infections (fascioliasis), with cure rates often exceeding 90 % in humans when dosed correctly at 10 mg/kg. It stands out because it affects both juvenile and mature flukes and is generally well tolerated. However, resistance and variable responses in livestock and some human cases underline the importance of appropriate use and follow-up testing.